Top Canada court upholds anti-terrorism law in unanimous ruling






OTTAWA (Reuters) – Canada‘s Supreme Court on Friday upheld an anti-terrorism law enacted after the September 11, 2001, attacks on the United States, ruling unanimously that those who choose to engage in terrorism must “pay a very heavy price.”


The law’s constitutionality was challenged by Mohammad Momin Khawaja, convicted in Canada of terrorism for involvement with a British group that had plotted unsuccessfully to set off bombs in London.






It was also challenged by two men accused of terrorism by the United States for trying to buy missiles or weapons technology for the Sri Lankan Tamil Tigers.


The court rejected arguments that the law’s definition of terrorism was overly broad. It upheld Khawaja’s life sentence and confirmed the orders to extradite the other two to the United States.


Khawaja, a Canadian of Pakistani descent, was the first to be convicted under the law. He was sentenced in 2008 to 10-1/2 years in prison, and his sentence was then extended to life after appeal by the government.


The trial judge noted that Khawaja referred to Osama Bin Laden as “the most beloved person to me in the … whole world, after Allah.” He was found to have participated in a terrorism training camp in Pakistan and to have designed a device dubbed the “hi fi digimonster” for detonating bombs.


“The appellant was a willing participant in a terrorist group,” Supreme Court Chief Justice Beverley McLachlin wrote in the 7-0 decision, adding that he was “apparently remorseless.”


“He was committed to bringing death on all those opposed to his extremist ideology and took many steps to provide support to the group. The bomb detonators he attempted to build would have killed many civilians had his plans succeeded.”


The law applies to any act committed for a political, religious or ideological purpose with the intention of intimidating the public by causing death or serious bodily harm, or substantial property damage, or causing serious interference with an essential service.


The court also ruled that Canada can proceed to extradite two men the United States has accused of involvement with the Tamil Tigers, which waged a bloody war for independence in Sri Lanka and is considered a terrorist organization by Washington and Ottawa.


The Canadian government declined to comment on when they would be extradited.


Piratheepan Nadarajah was alleged to have tried to purchase surface-to-air missiles and AK-47 assault rifles for the Tamil Tigers from an undercover officer posing as a black-market arms dealer on Long Island, New York.


The other man, Suresh Sriskandarajah, was alleged to have helped Tamil Tigers get electronic equipment, submarine and warship design software and communications equipment.


They surrendered to the government ahead of the court decision, their lawyers said.


BEYOND ‘LEGITIMATE EXPRESSION’


The court disagreed that the federal law’s terrorism provisions had put a chilling effect on Canadians’ freedom of expression and was disproportionately broad.


“Only individuals who go well beyond the legitimate expression of a political, religious or ideological thought, belief or opinion, and instead engage in one of the serious forms of violence – or threaten one of the serious forms of violence – listed (in the law) need fear liability under the terrorism provisions of the Criminal Code,” McLachlin wrote.


She quoted with approval the appeals court decision in the Khawaja case that faulted the Ottawa trial judge’s sentence for failing to send a “clear and unmistakable message that terrorism is reprehensible and those who choose to engage in it will pay a very heavy price.”


The original sentence of 10-1/2 years does “not approach an adequate sentence for such acts,” she concluded.


Khawaja’s lawyer, Lawrence Greenspon, said it was a “terrible day” for his client and said too often people were investigated or prosecuted for their religious or political beliefs.


“It’s a … very unfortunate ruling for minorities in this country, and we’re extremely disappointed with the result,” he told reporters in the foyer of the Supreme Court.


Justice Minister Rob Nicholson said the decision was important as Canada was not immune to the threat of terrorism. “The court sent a strong message that terrorism will not be treated leniently in Canada,” he said.


The cases are Mohammad Momin Khawaja v. Her Majesty the Queen. (Ont) (34103); Suresh Sriskandarajah v. United States of America, Minister of Justice and Attorney General of Canada (34009), Piratheepan Nadarajah v. United States of America, Minister of Justice and Attorney General of Canada (34013).


(Additional reporting by Louise Egan; Editing by Jackie Frank and Xavier Briand)


Canada News Headlines – Yahoo! News


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“Homeland” leads old favorites in Golden Globes TV race






LOS ANGELES (Reuters) – Cable shows got more Golden Globe nominations for television than traditional network programs on Thursday as HBO‘s political movie “Game Change” and Showtime‘s psychological thriller series “Homeland,” – one of last year’s big winners – led the race.


“Homeland” led the TV drama category with four nominations including best drama, best actor for Damian Lewis and best actress for Claire Danes in her role as a bi-polar CIA agent tracking down a home-grown Muslim extremist.






The show faces stiff competition from British aristocratic drama “Downton Abbey, which also won an acting nod for Michelle Dockery, along with “Breaking Bad,” “Boardwalk Empire,” and newcomer “The Newsroom.”


“‘Homeland’ fans seemed to be a little more split on whether creatively the second season was as successful as the first season so it’ll be curious if that ends up impacting the show’s chances in terms of taking home the awards,” James Hibberd, senior staff writer at Entertainment Weekly, told Reuters.


Downtown Abbey” creator Julian Fellowes told Reuters: “We’re up against the big boys now, but the whole thing is very flattering and exciting.”


He added: “The themes of the show are pretty international, they’re about adjusting to change and being caught out by what life does to you…all of that is common to every country.”


HBO movie “Game Change,” about the surprise selection of Sarah Palin as John McCain’s running mate in the 2008 presidential campaign, landed five nods in the miniseries/movie category, including for actors Julianne Moore and Woody Harrelson.


“‘Game Change’ is pure awards bait. It’s a well-done, smart political drama based on a book, with a certain amount of left-wing political slant and it’s very much the type of movie you’d expect awards voters to like,” Hibberd said.


New HBO drama “The Newsroom” bumped long-time awards favorite “Mad Men” from the best drama category, surprising many who believed the stylish advertising series was a shoo-in.


“The Globes tend to like the glamorous and sophisticated dramas with big city settings and they tend to shy away from gritty, rural Americana dramas…about sweaty guys with guns instead of charming men in suits, like ‘The Newsroom’ and ‘Boardwalk Empire,’” Hibberd said.


He noted that the only exception was “Breaking Bad,” which finally made the best drama category this year after four seasons on air.


Other notable snubs included HBO‘s epic fantasy drama “Game of Thrones,” which failed to pick up any nominations, and Ryan Murphy’s miniseries “American Horror Story: Asylum” which landed one best actress nod for Jessica Lange, who took home the award for 2012.


‘MODERN FAMILY’ LEADS COMEDY RACE


While last year’s Golden Globes picked newcomers over staple awards favorites for leading nominees, this year’s comedy categories saw the return of many old faces, including “Modern Family,” which led the comedy race with three nods.


Comedians Tina Fey and Amy Poehler, who will be hosting the awards ceremony on January 13, each landed a best comedy actress nod in the television race for their long-popular NBC comedies – Fey for “30 Rock” and Poehler for “Parks and Recreation.”


“You can be sure that the hosts are going to have fun with this during the telecast, they’re going to find ways to play off this during their presentation,” Hibberd said.


Fey and Poehler will replace Ricky Gervais at the awards gala dinner, after the British comedian helmed the Globes with his risqué dry humor for three years.


HBO‘s raunchy new comedy “Girls” earned two key nominations in the best TV comedy category and best comedy actress for Lena Dunham, while Showtime‘s new satire “House of Lies” landed the show’s lead Don Cheadle a best actor nod.


With the exception of NBC’s musical comedy “Smash” in the best comedy series category, no new network comedies managed to break into key races, which Hibberd attributed to a “disappointing” fall season.


Cable channel HBO picked up 17 nominations and Showtime garnered 7 across all major television categories. Networks ABC had 5, CBS and NBC got 4, and Fox got 2.


(Reporting By Piya Sinha-Roy, editing by Jill Serjeant)


TV News Headlines – Yahoo! News


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Xbox 720 and PlayStation 4 might not launch until 2014






Nintendo (NTDOY) says its kickstarted the next generation of video game consoles with the Wii U. But considering its graphics and processing power are comparable to Microsoft’s (MSFT) Xbox 360 and Sony’s (SNE) PlayStation 3, hardcore gamers are holding out for the next Xbox, tentatively dubbed “Xbox 720,” and next-generation PlayStation, tentatively called PS4. Rumors insist Microsoft and Sony will both launch their next consoles in the fall of 2013, but SemiAccurate, the website that first reported the next Xbox could see a delay, says there is a bit of confusion over how the consoles are progressing and when they’ll arrive.


According to SemiAccurate, the next Xbox is currently code-named “Kryptos” and not “Durango” anymore, and the next PlayStation is now code-named “Thebes” rather than “Orbis.” The PS4 will reportedly have a 28-nanometer AMD chipset and will be produced by IBM or Global Foundries.






SemiAccurate says the PS4 could be released in spring of 2014 or fall 2014 and the Xbox 720 could still see the delay from fall 2013 to 2014.


Xbox World claimed last month that the next Xbox will have a Blu-ray disc drive, Kinect 2.0, directional audio, TV output and input, an “innovative controller” and support for augmented reality glasses – all packaged in a magnesium alloy shell that will supposedly use the same patented “VaporMg” process found on the Surface tablet.


Not only that, but Microsoft is also working on an “Xbox Lite,” according to reports from earlier this year.


As for PS4 details, VG247 reported in November that Sony has already sent out various developer kits with specs including 16GB of RAM and 256GB of storage.


Sony and Microsoft are expected to reveal their next consoles at E3 2013 this coming June.


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U.S. to finalize stricter soot standards on Friday






WASHINGTON (Reuters) – The Obama administration will finalize stronger limits on harmful soot pollution from power plants and diesel engines on Friday, two health groups said.


The new standards, which the Environmental Protection Agency was under court order to finalize, will limit annual average soot emissions to about 12 micrograms per cubic meter of air from the standard of 15 micrograms set in 1997, the groups said.






Individual states will be responsible for deciding how to limit the emissions of fine particulates, which can threaten the elderly, people with heart disease and children.


When the EPA proposed the rules in June it said only six counties in California, Arizona, Alabama, Michigan and Montana are out of compliance with the standard. It also said the reduction in health bills from the standard would far outweigh the costs to industry.


(Reporting by Timothy Gardner; Editing by Gerald E. McCormick and Bob Burgdorfer)


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At least 27 dead, mostly children, in Conn. school shooting



More than two dozen people, mostly elementary school children, were shot
and killed at a Newtown, Conn., elementary school this morning, federal
and state sources tell ABC News.



The massacre involved two gunmen and prompted the town of Newtown to
lock down all of its schools and draw SWAT teams to the school,
authorities said today.



One shooter is dead and a manhunt is on for a second gunman. Police are
searching cars. One shooter was described as a 24-year-old armed with
four weapons and wearing a bullet vest, sources told ABC News.



It's unclear how many people have been shot, but 27 people, mostly
children are dead, multiple federal and state sources tell ABC News.
That number could rise, officials said.



President Obama was briefed on the shooting by FBI Director Bob Mueller.



It is the worst shooting in a U.S. elementary school in recent memory and exceeds the carnage at 1999 Coumbine High School
shooting in which 13 died and 24 were injured.



The Newtown shooting comes just three days after masked gunman Jacob
Roberts opened fire in a busy Oregon, mall killing two before turning
the gun on himself.



Today's shooting occurred at the Sandy Hook Elementary School, which
includes 450 students in grades from kindergarten through fourth grade.
The town is located about 12 miles east of Danbury.



Watch Upcoming State Police News Conference Live at ABCNews.com



State Police received the first 911 call at 9:41a.m. and immediately
began sending emergency units from the western part of the state.
Initial 911 calls stated that multiple students were trapped in a
classroom, possibly with a gunman, according to a Connecticut State
Police source.



A photo from the scene shows a line of distressed children being led out of the school.



LIVE UPDATES: Newtown, Conn., School Shooting



Three patients have been taken to Danbury Hospital, which is also on lockdown, according to the hospital's Facebook page.



"Out of abundance of caution and not because of any direct threat
Danbury Hospital is under lockdown," the statement said. "This allows us
simply to focus on the important work at hand."



CLICK HERE for more photos from the scene.



Newtown Public School District secretary of superintendent Kathy June
said in a statement that the district's school were locked down because
of the report of a shooting. "The district is taking preventive measures
by putting all schools in lockdown until we ensure the safety of all
students and staff."



State police sent SWAT team units to Newtown.



All public and private schools in the town are on lockdown.



"We have increased our police presence at all Danbury Public Schools due
to the events in Newtown. Pray for the victims," Newtown Mayor Boughton
tweeted.



State emergency management officials said ambulances and other units were also en route and staging near the school.



A message on the school district website says that all afternoon
kindergarten is cancelled today and there will be no mid-day bus runs.

Also Read

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UPDATE 3-Cricket-Hughes shines as Australia reach 299-4






* Hughes falls just short of century


* Clarke and Hussey combine for 101






* Welegedera takes 3-99 (Adds quotes)


HOBART, Dec 14 (Reuters) – Phil Hughes made a solid 86 on his return to test cricket before Michael Clarke and Mike Hussey took up the running and steered Australia to 299 for four at close of play on the first day of the first test against Sri Lanka on Friday.


Hughes was the only batsmen to fall in the final session, lasting only a couple of overs after lunch before being bowled through the gate by Chanaka Welegedera, giving the Sri Lankan seamer his third wicket of the day.


Clarke, who had made 70 not out, and Hussey, unbeaten on 37, batted through the remainder of the day and if the evidence of their prolific partnerships in the recent series against South Africa is anything to go by, will take some shifting.


“Overall, 299 for four puts the ball in our court,” said Hughes. “I thought we were outstanding today. It really gives us momentum going into tomorrow.”


Sri Lanka’s bowlers, dubbed this week as the worst pace attack ever to tour Australia by former test bowler Rodney Hogg, made life uncomfortable for the batsmen at times but struggled for any real penetration under cloudy skies at Bellerive Oval.


“I think we showed we can put Australia under pressure and hopefully the bowlers will be fresh in the morning and we can get them out for less than 100 additional runs,” said Welegedera, who finished with 3-99 on his return after nine months out injured.


Clarke, who passed 1,400 runs for the year, has now put on 731 runs in partnerships with Hussey in the last four tests and will be looking to plunder a few more on Saturday despite taking a couple of painful knocks to his legs.


Friday, however, belonged to Hughes.


The lefthander was recalled to the side on the back of good domestic form following the retirement of Ricky Ponting at the end of the series against the Proteas.


The 24-year-old reached his fourth test half century with a square drive for three runs and then initially accelerated towards a century, most notably with an ugly but effective slog for six off spinner Rangana Herath.


CALAMITOUS RUNOUT


On the ground where his second spell as a test batsman ended amid questions about his technique after two failures against New Zealand last year, Hughes scored eight fours and one six in his 166-ball knock before Welegedera struck with a superb ball.


“It was nice to get a few,” he said. “It would have been nice to get a few more and get into three figures.”


Australia had lost openers Ed Cowan (four) and David Warner in the opening session, the latter run out for 57 on the stroke of lunch after a calamitous misunderstanding with Hughes.


Shane Watson, dropping down to fourth in the batting order to allow Hughes to come in at number three, followed them to the pavilion for 30 shortly before tea, the victim of an exceptional diving catch in the slips by skipper Mahela Jayawardene.


That was a second wicket for Welegedera and a measure of redemption for the bowler after he had Hughes caught behind for 77 only for the umpire to call a no ball.


Welegedera had also made the early breakthrough for the tourists when Cowan tried to pull a short delivery only for the ball to catch him high on the bat and carry to mid-on where Shaminda Eranga took a simple catch.


It could have been even better for the Sri Lankans, who were only centimetres away from the perfect start to the morning after Clarke had won the toss and elected to bat.


Cowan edged the second delivery of the day from Nuwan Kulasekara to the slips but Angelo Mathews was just unable to get his hands to it, despite an athletic dive. (Editing by Peter Rutherford)


Australia / Antarctica News Headlines – Yahoo! News


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TLC’s “Best Funeral Ever” runs Reality TV into the ground






LOS ANGELES (TheWrap.com – TLC, which brought the world “Here Comes Honey Boo Boo” and “Sister Wives,” has hit new depths: The new one-hour special “Best Funeral Ever” will follow dead people’s journey to the grave.


The network announced Thursday that “Best Funeral Ever” will focus on the Golden Gate Funeral Home in Dallas, which prides itself on its unique theme funerals – or as Golden Gate calls them, “home-going celebrations.”






“A home-going is much different than a funeral, it’s a celebration,” Golden Gate CEO John Beckwith Jr. says of his company’s approach. “The Golden Gate experience is our version of the traditional African American home-going celebration. We do not produce generic funerals; everybody’s experience has to be different.”


In the case of “Best Funeral Ever,” that includes a Christmas-inspired funeral complete with elves, reindeer and snow and a barbecue-themed sendoff for a doo-wop singer who was well-known for a rib sauce jingle. A State Fair-themed funeral will allow a man whose disabilities prevented him from riding roller coasters to finally, um, experience the thrill rides, games and attractions he missed out on in life. (Sounds like a great sequel to “Weekend at Bernie’s.”)


“Best Funeral Ever,” which is produced by Park Slope Productions, will premiere December 26 at 8 p.m. – just in case you’re experiencing any residual Christmas cheer and need a reminder of your mortality.


TV News Headlines – Yahoo! News


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Selling flak jackets in the cyberwars






SAN FRANCISCO (Reuters) – When the Israeli army and Hamas trade virtual blows in cyberspace, or when hacker groups like Anonymous rise from the digital ether, or when WikiLeaks dumps a trove of classified documents, some see a lawless Internet.


But Matthew Prince, chief executive at CloudFlare, a little-known Internet start-up that serves some of the Web’s most controversial characters, sees a business opportunity.






Founded in 2010, CloudFlare markets itself as an Internet intermediary that shields websites from distributed denial-of-service, or DDoS, attacks, the crude but effective weapon that hackers use to bludgeon websites until they go dark. The 40-person company claims to route up to 5 percent of all Internet traffic through its global network.


Prince calls his company the “Switzerland” of cyberspace – assiduously neutral and open to all comers. But just as companies like Twitter, YouTube and Facebook have faced profound questions about the balance between free speech and openness on the Internet and national security and law enforcement concerns, CloudFlare‘s business has posed another thorny question: what kinds of services, if any, should an American company be allowed to offer designated terrorists and cyber criminals?


CloudFlare’s unusual position at the heart of this debate came to the fore last month, when the Israel Defense Forces sought help from CloudFlare after its website was struck by attackers based in Gaza. The IDF was turning to the same company that provides those services to Hamas and the al-Quds Brigades, according to publicly searchable domain information. Both Hamas and al-Quds, the military wing of the Palestinian Islamic Jihad, are designated by the United States as terrorist groups.


Under the USA Patriot Act, U.S. firms are forbidden from providing “material support” to groups deemed foreign terrorist organizations. But what constitutes material support – like many other facets of the law itself – has been subject to intense debate.


CloudFlare’s dealings have attracted heated criticism in the blogosphere from both Israelis and Palestinians, but Prince defended his company as a champion of free speech.


“Both sides have an absolute right to tell their story,” said Prince, a 38-year old former lawyer. “We’re not providing material support for anybody. We’re not sending money, or helping people arm themselves.”


Prince noted that his company only provides defensive capabilities that enable websites to stay online.


“We can’t be sitting in a role where we decide what is good or what is bad based on our own personal biases,” he said. “That’s a huge slippery slope.”


Many U.S. agencies are customers, but so is WikiLeaks, the whistle-blowing organization. CloudFlare has consulted for many Wall Street institutions, yet also protects Anonymous, the “hacktivist” group associated with the Occupy movement.


Prince‘s stance could be tested at a time when some lawmakers in the United States and Europe, armed with evidence that militant groups rely on the Web for critical operations and recruitment purposes, have pressured Internet companies to censor content or cut off customers.


Last month, conservative political lobbies, as well as seven lawmakers led by Ted Poe, a Republican from Texas, urged the FBI to shut down the Hamas Twitter account. The account remains active; Twitter declined to comment.


MATERIAL SUPPORT


Although it has never prosecuted an Internet company under the Patriot Act, the government’s use of the material support argument has steadily risen since 2006. Since September 11, 2001, more than 260 cases have been charged under the provision, according to Fordham Law School’s Terrorism Trends database.


Catherine Lotrionte, the director of Georgetown University’s Institute for Law, Science and Global Security and a former Central Intelligence Agency lawyer, argued that Internet companies should be more closely regulated.


“Material support includes web services,” Lotrionte said. “Denying them services makes it more costly for the terrorists. You’re cornering them.”


But others have warned that an aggressive government approach would have a chilling effect on free speech.


“We’re resurrecting the kind of broad-brush approaches we used in the McCarthy era,” said David Cole, who represented the Humanitarian Law Project, a non-profit organization that was charged by the Justice Department for teaching law to the Kurdistan Workers’ Party, which is designated by the United States as a terrorist group. The group took its case to the Supreme Court but lost in 2010.


The material support law is vague and ill-crafted, to the point where basic telecom providers, for instance, could be found guilty by association if a terrorist logs onto the Web to plot an attack, Cole said.


In that case, he asked, “Do we really think that AT&T or Google should be held accountable?”


CloudFlare said it has not been contacted about its services by the U.S. government. Spokespeople for Hamas and the Palestinian Islamic Jihad, told Reuters they contracted a cyber-security company in Gaza that out-sources work to foreign companies, but declined to comment further. The IDF confirmed it had hired CloudFlare, but declined to discuss “internal security” matters.


CloudFlare offers many of its services for free, but the company says websites seeking advanced protection and features can see their bill rise to more than $ 3,000 a month. Prince declined to discuss the business arrangements with specific customers.


While not yet profitable, CloudFlare has more than doubled its revenue in the past four months, according to Prince, and is picking up 3,000 new customers a month. The company has raked in more than $ 22 million from venture capital firms including New Enterprise Associates, Venrock and Pelion Venture Partners.


Prince, a Midwestern native with mussed brown hair who holds a law degree from the University of Chicago, said he has a track record of working on the right side of the law.


A decade ago, Prince provided free legal aid to Spamhaus, an international group that tracked email spammers and identity thieves. He went on to create Project Honey Pot, an open source spam-tracking endeavor that turned over findings to police.


Prince’s latest company, CloudFlare, has been hailed by groups such as the Committee to Protect Journalists for protecting speech. Another client, the World Economic Forum, named CloudFlare among its 2012 “technology pioneers” for its work. But it also owes its profile to its most controversial customers.


CloudFlare has hosted 4Chan, the online messaging community that spawned Anonymous. LulzSec, the hacker group best known for targeting Sony Corp, is another customer. And since last May, the company has propped up WikiLeaks after a vigilante hacker group crashed the document repository.


Last year, members of the hacker collective UgNazi, whose exploits include pilfering user account information from eBay and crashing the CIA.gov website, broke into Prince’s cell phone and email accounts.


“It was a personal affront,” Prince said. “But we never kicked them off either.”


Prince said CloudFlare would comply with a valid court order to remove a customer, but that the Federal Bureau of Investigation has never requested a takedown. The company has agreed to turn over information to authorities on “exceedingly rare” occasions, he acknowledged, declining to elaborate.


“Any company that doesn’t do that won’t be in business long,” Prince said. But in an email, he added: “We have a deep and abiding respect for our users’ privacy, disclose to our users whenever possible if we are ordered to turn over information and would fight an order that we believed was not proper.”


Juliannne Sohn, an FBI spokeswoman, declined to comment.


Michael Sussmann, a former Justice Department lawyer who prosecuted computer crimes, said U.S. law enforcement agencies may in fact prefer that the Web’s most wanted are parked behind CloudFlare rather than a foreign service over which they have no jurisdiction.


Federal investigators “want to gather information from as many sources as they can, and they’re happy to get it,” Sussmann said.


In an era of rampant cyber warfare, Prince acknowledged he is something of a war profiteer, but with a wrinkle.


“We’re not selling bullets,” he said. “We’re selling flak jackets.”


(Reporting By Gerry Shih in San Francisco and Nidal al-Mughrabi in Gaza; editing by Jonathan Weber and Claudia Parsons)


Internet News Headlines – Yahoo! News


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In challenge to personalized cancer care, DNA isn’t all-powerful






NEW YORK (Reuters) – The cancer cells were not behaving the way the textbooks say they should. Some of the cells in colonies that were started with colorectal tumor cells were propagating like mad; others were hardly multiplying. Some were dropping dead from chemotherapy and others were no more slowed by the drug than is a tsunami by a tissue. Yet the cells in each “clone” all had identical genomes, supposedly the all-powerful determinant of how cancer cells behave.


That finding, published online Thursday in Science, could explain why almost none of the new generation of “personalized” cancer drugs is a true cure, and suggests that drugs based on genetics alone will never achieve that holy grail.






Scientists not involved in the study praised it for correcting what Dr. Charis Eng, an oncologist and geneticist who leads the Genomic Medicine Institute at the Cleveland Clinic, called “the simple-minded” idea that tumor genomes alone explain cancer.


Calling the study “very exciting,” she said the finding underlines that a tumor’s behavior and, most important, its Achilles heel depend on something other than its DNA. Her own work, for instance, has shown that patients with identical mutations can have different cancers.


The core premise of the leading model of cancer therapy is that cells become malignant when they develop mutations that make them proliferate uncontrolled. Find a molecule that targets the “driver” mutation, and a pharmaceutical company will have a winner and patients will be cancer-free.


That’s the basis for “molecularly targeted” drugs such as Pfizer’s Xalkori for some lung cancers and Novartis’s Gleevec for chronic myeloid leukemia. When those drugs stop working, the dogma says, it is because cells have developed new cancer-causing mutations that the drugs don’t target.


In the new study, however, scientists found that despite having identical genetic mutations, colorectal cancer cells behaved as differently as if they were genetic strangers. The findings challenge the prevailing view that genes determine how individual cells in a solid tumor behave, including how they respond to chemotherapy and how actively they propagate.


If DNA is not the sole driver of tumors’ behavior, said molecular geneticist John Dick of the Princess Margaret Cancer Centre in Toronto, who led the study, it suggests that, to vanquish a cancer entirely, drugs will have to target their non-genetic traits too, something few drug-discovery teams are doing.


Genomes are what cutting-edge clinics test for when they try to match a patient’s tumor to the therapy most likely to squelch it.


For their study, Antonija Kreso, Catherine O’Brien and other scientists under Dick’s direction took colorectal cancer cells from 10 patients and transplanted them into mice. They infected the cells with a special virus that let them track each cell, even after it divided and multiplied and was transplanted into another mouse, then another and another, through as many as five such “passages.”


Only one in 10,000 tumor cells was responsible for keeping the cancer growing, the scientists found – in some cases for 500 days of repeated transplantation from one mouse to the next. Genetically-identical tumor cells stopped dividing within 100 days even without treatment.


Tumor cells that were not killed by chemotherapy – the scientists used oxaliplatin, a colon-cancer drug sold by Sanofi as Eloxatin – had the same mutations as cells that were. The survivors tended to be dormant, non-proliferating ones that suddenly became activated, causing the tumor to grow again. Yet the cells – dormant or active, invulnerable to chemo or susceptible – had identical genomes.


“I thought we’d be able to look at the genetics that let some cells propagate, or not be susceptible to chemotherapy, but lo and behold there was no genetic difference,” said Dick. “That goes against a main dogma of the cancer enterprise: that if a tumor comes back after treatment it’s because some cells acquired mutations that made them resistant.”


That’s true in some cases, he said, “but what our data are saying is, there are other biological properties that matter. Gene sequencing of tumors is definitely not the whole story when it comes to identifying which therapies will work.”


The results were surprising enough, Dick said, that experts reviewing the paper for Science asked him to run additional tests to make sure the cells that behaved so differently were in fact genetic twins. He did, they were, and Science accepted the paper.


Other experts also praised the work, saying it supported the growing suspicion in the field that personalized cancer therapy is oversimplistic, at least in how it’s sold to the public.


“It’s not as simple as just sequencing mutations to tailor therapies to each tumor,” said surgical oncologist Dr. Steven Libutti of the Montefiore Einstein Center for Cancer Care in New York City. “In my mind, the findings are not unexpected. Other things besides genes matter: the environment in which a tumor is growing, for instance, plays an important role in whether therapy will be effective.”


Rather than targeting DNA alone, the Toronto scientists suspect, effective therapies would also take aim at what phase of its cycle a cell is in (dormant, growing or dividing, for example), which of its genes are activated, whether it sits in a region of the tumor that is starved of oxygen, and other non-genetic properties.


Nudging tumor cells out of their dormant phase and into their growth cycles, for instance, could make them more susceptible to chemotherapy, which generally targets rapidly dividing cells.


“Our findings raise questions about the resources put into sequence, sequence, sequence,” said Dick. “That has led to one kind of therapeutic” – molecularly-targeted drugs – “but not the cures the public is being promised.”


(Reporting by Sharon Begley; editing by Claudia Parsons)


Diseases/Conditions News Headlines – Yahoo! News


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Why Hillary Clinton won't get a break from public life

By Walter Shapiro

The envelope, please. The 2012 award for the most candid comment by a prominent public official goes to Hillary Clinton. Her uncharacteristic burst of honesty adds a layer of complexity to the premature speculation about her political future.

In an interview with the New York Times columnist Gail Collins, Clinton revealed her fantasy for 2013 after she takes her final globe-girdling flight as secretary of state: “I just want to sleep and exercise and travel for fun. And relax. It sounds so ordinary, but I haven’t done it for 20 years. I would like to see whether I can get untired.”

The dream seems so modest: to see whether her 65-year-old body can recover from years of too much stress and too little sleep. But Hillary Clinton, Private Citizen will soon have to confront the world clamoring at her door with its own set of expectations, requests and demands for clarity about running for president in 2016.

Friends who want her to speak, receive an award or grace a charitable event have been told to hold off asking until April or May, according to a front-page story in last Sunday’s Times by Jodi Kantor. As an indication of the coming news media frenzy, the New York Times is already lavishing more space on the whither-Hillary beat than the tabloids devote to Lindsay Lohan and Kate Middleton. Combined.

What this means, of course, is no rest for the weary and world-famous.

Sure, Clinton may take two months or so off, interspersed with such restful tasks as house-hunting (the Clintons are said to be tempted by the Hamptons), hiring a staff, talking to a lecture agent, contemplating a book and presumably chatting with the most persistent political callers. If she does manage to sneak off on a vacation (Iowa is always lovely in March), rest assured that the paparazzi and the political press will be close behind.

Try as she might, Clinton will find it difficult, if not impossible, to avoid being entangled in a web of obligation. Legions of friends (and, unlike the norm in politics, her longstanding friendships appear genuine) will ask her for time-consuming favors that cannot all be rejected. The do-gooder side of her nature will propel her into too many events and trips for worthy causes. And, as a Clinton, she knows all too well how easily political supporters bristle when their egos are not being stroked.

I first interviewed Hillary Clinton in the governor’s mansion in Little Rock in 1992. And since then, I have made my contributions to that mushrooming branch of journalism called Hillary Studies. This experience has left me with an appreciation for her complexity as a person—and a reluctance to assume that her only motivations are ambition and a feminist obligation to seize the opportunity to become the first woman president.

So I have no idea if she will run in 2016, and I doubt if she does either. Clinton’s State Department spokesman Philippe Reines got it right when he cautioned the Times, “Be very wary of those pretending to bear actual knowledge.” Over the next two years, everyone in politics could learn enough classical Greek to read “The Iliad” in the time that they will devote to devouring speculative articles built around anonymous quotes from “Clinton friends.”

If she does make another bid for the White House, Clinton will have been granted the ultimate luxury in presidential politics. And that is to take the time in advance to contemplate what she would want to accomplish in the White House rather than having to focus solely on the mechanics for getting there.

The only post-war presidents who have had a chance to think seriously about governing from the White House before they took office were Dwight Eisenhower, Richard Nixon and Ronald Reagan. And in politics, as in country music, two out of three ain’t bad.

Since Reagan in 1980, every new president simultaneously held a normally demanding day job (vice president, governor or senator) when he was elected. Bill Clinton, for example, rushed from a 1990 reelection campaign as Arkansas governor to a roller-coaster race for the White House to president-elect without a moment for reflection. And this careening from crisis to crisis contributed to Clinton’s disastrous first two years in the White House.

But with Hillary Clinton it could be different. She has the right instincts about what she wants to do with the long-awaited gift of free time. Reading something other than briefing books and classified memos would add to her already impressive breadth of her knowledge. Unstructured conversations with old friends and major thinkers might lead her in surprising intellectual directions. Such a laid-back interlude would make her, if elected, a better and more thoughtful president in 2017.

That is the theory. But the sad truth is that Hillary Clinton will never be allowed to go off the grid for long. Her celebrity is too great; the clamor for a piece of her political future is too intense.

So Clinton will dutifully do what is expected of her as a private citizen: attending an international conference in Bangladesh, holding an off-the-record meeting with potential political donors, writing a book, making a few policy addresses on national security. And someday, if she does return to the White House in 2017, she will still fantasize about being untired.


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