Nintendo’s Wii U: First Impressions

GamePad

The Wii U GamePad has a 6.2-inch touchscreen.

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[More from Mashable: Meet the Super Fan Who Waited in Line for a Month for a Wii U [VIDEO]]

Nintendo‘s newest console has only been available for one day, but that’s still enough time for early-bird consumers to get their hands on the Wii U, and test out its features and games.

We spent the last 24 hours playing with the Wii U, and have organized our early thoughts on the system. Read on if you’re on the fence about buying one.

[More from Mashable: Toys ‘R’ Us Says Wii U Pre-Order Shipments May Be Delayed]

Out of the Box

Setting up the Wii U is easy, but installing the software is more of a process. Nintendo issued a day-one patch to activate features such as MiiVerse, the company’s social features; this means users will spend between one to three hours (depending on connection speed) downloading and installing a patch that bricks their system. Not a great way to greet consumers excited to play your games. But there’s a chance that servers won’t be as busy in the coming weeks, so download times may improve. Each game I inserted had its own patch too, which users have to install on the second playthrough.

After getting through the patch, user still face an involved setup. They have to create their Mii avatar before they start playing, and create a Nintendo Network ID for network play. Users must also set up the GamePad’s universal remote functionality, which is thankfully the easiest part of the process. They only have to pick their TV manufacturer (the Wii U knows what to do next). The GamePad controls volume, input source and channels.

Look and Feel

The GamePad is the Wii U’s main portal, so users need it to access all the relevant menus (the console shows a different menu from the television); here, users can launch applications by touch. The default view includes apps such as Netflix, Hulu Plus, Amazon Video Services and YouTube; but only Netflix is available now, which seems a bit like false advertising. Loading other options, such as the Nintendo eShop, requires pressing the Home button on the controller, which is unintuitive at first. But soon, the button quickly becomes a handy way to navigate to other parts of the Wii U, like the upcoming Nintendo TVii.

The most troublesome thing about the console is that everything moved slowly; launching games and apps took a long time. I felt like I spent awhile looking at a spinning blue circle.

Wii U games definitely take advantage of the console’s ability to support high-definition graphics. Cartoony games, such as Scribblenauts Unlimited or Nintendo Land look beautiful. For games such as ZombiU, which are supposed to appear more realistic, users might be disappointed. This system is supposed to be the next-generation of gaming consoles — meant to outshine the Xbox 360 — but I can’t say it achieves that.

The GamePad

Pre-launch, Nintendo has spent much of its time crowing about the features of the GamePad, a hybrid touch screen and controller that’s central to the Wii U. The first thing I noticed is its large size; but after spending a few hours with the GamePad, I’ve concluded that it won’t weigh you down like an iPad, yet is substantial enough that it doesn’t feel like a toy (though the glossy finish makes it look like one.)

Unfortunately, the GamePad takes some getting used to as an actual controller, especially for games that require more than simple controls or the gyroscope. My biggest complaint is that Nintendo bucked all gaming-controller tradition by swapping the position of the right analog stick and the four letter buttons. Anyone who has played any other modern console (including Nintendo’s own GameCube) knows instinctively that the analog stick goes below the buttons; but Nintendo flipped them on both the GamePad and the Pro Controller. If the company is only targeting non-gamers, they won’t notice; but this will be a difficult change for many others. Despite this drawback, the buttons, and especially triggers, feel good.

The GamePad is mostly dominated by the 6.2-inch touch screen with a passable resolution: 854 x 480. The most appealing feature of the Wii U — that users can play games or watch movies entirely on the GamePad — may be spoiled for some looking for HD crispness. Still, I watched a whole episode of Portlandia from Netflix on the GamePad, and also spent time playing New Super Mario Bros. U with the television off. Being able to isolate your gameplay to a smaller screen is very novel, and one of my favorite parts of the system.

Games

Nintendo’s Wii U has a better launch lineup coming out, compared to other consoles — but only a few titles stick out. Almost everyone I talked to in line at the Nintendo World store during the Wii U launch wanted New Super Mario Bros. U or ZombiU, both of which are fun titles. Nintendo Land, which is a pack-in if users purchase the Deluxe model, is going to be a huge hit at parties; from what I’ve seen so far, it has some engrossing minigames. I haven’t cracked open Scribblenauts Unlimited yet, but in demos it looks like a very promising title that would go well with a touch screen.

Some non-exclusive titles on other consoles are also appealing. I’m looking forward to digging in to Epic Mickey 2 and Tekken Tag Tournament 2. While the system had 24 launch titles, many more are expected to debut in the coming months.

I plan to spend Thanksgiving week exploring the Wii U, and will write a more detailed report on whether it’s the right console for gamers, families or casual users.

This story originally published on Mashable here.

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PIRG warns of toy dangers but finds fewer of them

WASHINGTON (AP) — Toys are safer than ever before, consumer advocates say, but parents should remain vigilant in keeping their little ones away from powerful magnets and small items that can easily cause choking.

“The main trend that we saw this year was that we didn’t find as many toxic toys as we thought we would,” said Nasima Hossain, a public health advocate for U.S. Public Interest Research Group.

PIRG examined more than 200 toys on store shelves at major retailers and dollar stores and tested about three dozen toys for lead and chemicals called phthalates, which are used to make plastic products softer but have been linked to reproductive defects and other health problems. A 2008 product safety law ushered in new standards for children’s products, including strict limits on lead and phthalates allowed in toys.

Of the toys tested, only one — a Morphobot action figure — turned up lead levels that exceeded the new stricter federal limit on how much metal can be in the toy. For phthalates, the toys all met the federal standard for what’s allowed, though a Dora the Explorer backpack had levels that would trigger disclosure under Washington state and California law, the report said.

Small toys that could choke children and loud toys that could possibly lead to hearing loss were the primary concern of this year’s report.

A Dora the Explorer guitar and a set of colorful toy car keys for infants were cited for being excessively loud. Play food sets of everything from little strawberries to miniature sausage as well as small dragster cars that had tiny rubber traction bands on the wheels that could come loose were all listed as small enough to cause a child to choke.

The group also highlighted renewed concerns about magnets, especially the high-powered magnets in executive desktop toys for adults or a finger-play magnet toy for kids called Snake Eggs that PIRG found at a dollar store.

PIRG cited government estimates of 1,700 emergency room visits between 2009 and 2011 involving the ingestion of high-powered magnets. Most cases involved children between 4 and 12 years old. Older children have accidentally ingested the balls while trying to mimic tongue piercings. The magnets, such as the ones in the popular Buckyball desktop toys, can cling together if swallowed, pinch internal tissue and lead to serious injuries.

The Toy Industry Association’s Stacy Leistner says his group agrees that strong magnets are a risk for children and shouldn’t be available to them.

The Consumer Product Safety Commission this summer sued New York-based Maxfield and Oberton, the maker of the Buckyball desktop toys, to stop their sale. The finger-fidget toys are designed for adults, but CPSC said it was seeing too many injuries involving children.

Maxfield has maintained the toys are for adults, marketed to adults and carry clear warning labels — but it announced last month that it would stop making the Buckyball series. CPSC is considering a ban on high-powered magnet sets.

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Hamas leader: Cease-fire with Israel near

JERUSALEM (AP) — A diplomatic push to end Israel's nearly weeklong offensive in the Gaza Strip gained momentum Tuesday, with Egypt's president predicting that airstrikes would end within hours and Israel's prime minister saying his country would be a "willing partner" to a cease-fire with the Islamic militant group Hamas.

As international diplomats raced across the region to cement a deal, a senior Hamas official said an agreement was close even as relentless airstrikes and rocket attacks between the two sides continued. President Barack Obama dispatched Secretary of State Hillary Rodham Clinton to the Mideast from Cambodia, where she had accompanied him on a visit.

"We haven't struck the deal yet, but we are progressing and it will most likely be tonight," Moussa Abu Marzouk said Tuesday from Cairo, where cease-fire talks were being held.

Egyptian President Mohammed Morsi, perhaps the most important interlocutor between Hamas, which rules the Palestinian territory, and the Israelis, said the negotiations between the two sides will yield "positive results" during the coming hours.

In Brussels, a senior official of the European Union's foreign service said a cease-fire would include an end of Israeli airstrikes and targeted killings in Gaza, the opening of Gaza crossing points and an end to rocket attacks on Israel. The official spoke on condition of anonymity because he was not authorized to speak to the media.

Violence raged on as the talks continued. An airstrike late Tuesday killed two journalists who work for the Hamas TV station, Al-Aqsa, according to a statement from the channel. The men were in a car hit by an airstrike, Gaza health official Ashraf al-Kidra said. Israel claims that many Hamas journalists are involved in militant activities. Earlier this week it targeted the station's offices, saying it served as a Hamas communications post.

By Tuesday, 128 Palestinians, including at least 54 civilians, were killed since Israel began an air onslaught that has so far included nearly 1,500 strikes. Some 840 people have been wounded, including 225 children, Gaza health officials said.

Three Israeli civilians have also been killed and dozens wounded since the fighting began last week, the numbers possibly kept down by a rocket-defense system that Israel developed with U.S. funding. More than 1,000 rockets have been fired at Israel this week, the military said.

Late Tuesday, a Palestinian rocket hit a house in the central Israeli city of Rishon Letzion, wounding two people and badly damaging the top two floors of the building, police spokesman Micky Rosenfeld said.

With the death toll rising, the international community stepped up efforts to bring a halt to the fighting that began last Wednesday with an Israel's assassination of the Hamas military chief.

"If a long-term solution can be put in place through diplomatic means, then Israel would be a willing partner to such a solution. But if stronger military action proves necessary to stop the constant barrage of rockets, Israel wouldn't hesitate to do what is necessary to defend our people," Israeli Prime Minister Benjamin Netanyahu said during a joint press conference in Jerusalem with visiting U.N. chief Ban Ki-moon.

Ban condemned Palestinian rocket attacks, but urged Israel to show "maximum restraint."

"Further escalation benefits no one," he said.

Minutes before Ban's arrival in Jerusalem from Egypt, Palestinian militants fired a rocket toward the holy city. Earlier Tuesday, a man identified as Hamas' militant commander urged his fighters to keep up attacks on Israel, even as Israeli airstrikes killed a senior Hamas militant identified as Amin al-Dada and five others in a separate attack on a car, according to Gaza health officials.

Israeli warplanes dropped leaflets on several Gaza neighborhoods asking residents to evacuate and head toward the center of Gaza City along specific roads. The army "is not targeting any of you, and doesn't want to harm you or your families," the leaflets said. Palestinian militants urged residents to ignore the warnings, calling them "psychological warfare."

Clinton was scheduled to meet with Netanyahu in Jerusalem, Palestinian President Mahmoud Abbas in the West Bank and Egyptian leaders in Cairo. Turkey's foreign minister and a delegation of Arab League foreign ministers traveled to Gaza on a separate truce mission. Airstrikes continued to hit Gaza even as they entered the territory.

"Turkey is standing by you," Turkish Foreign Minister Ahmet Davutoglu told the Hamas prime minister in Gaza, Ismail Haniyeh. "Our demand is clear. Israel should end its aggression immediately and lift the inhumane blockade imposed on Gaza."

It was unclear how diplomatic efforts to achieve a cease-fire and stave off a threatened Israeli ground invasion into Gaza were hampered by the hard-to-bridge positions staked out by both sides — and by the persistent attacks. Tens of thousands of Israeli soldiers have been dispatched to the Gaza border in case of a decision to invade.

Residents of Jerusalem ran for cover Tuesday as sirens sounded after Palestinians fired a rocket toward the holy city for the second time since the fighting started last Wednesday.

Rosenfeld said the rocket landed harmlessly in an open area in Gush Etzion, a collection of Jewish West Bank settlements southeast of the city. Last Friday's attempt to hit Jerusalem, nearly 80 kilometers (50 miles) from Gaza, landed in the same area. No one was wounded in either attack.

Jerusalem had previously been considered beyond the range of Gaza rockets — and an unlikely target because it is home to the Al-Aqsa Mosque compound, Islam's third-holiest shrine.

In a sign of the difficulty diplomats will have in forging such a cease-fire, a man identified as Mohammed Deif, Hamas' elusive military commander, urged his fighters to keep up attacks on Israel.

Speaking from hiding on Hamas-run TV and radio, Deif said Hamas "must invest all resources to uproot this aggressor from our land," a reference to Israel.

Deif is one of the founders of Hamas' military wing and was its top commander until he was seriously wounded in an Israeli airstrike in 2003. He was replaced as the de facto leader by Ahmed Jabari, who was assassinated by Israel last week in the opening salvo of its latest Gaza offensive.

The U.S. considers Hamas, which has killed hundreds of Israelis in suicide and other attacks, to be a terror group and does not meet with its officials. The Obama administration blames Hamas for the latest eruption of violence and says Israel has the right to defend itself. At the same time, it has warned against a ground invasion, saying it could send casualties spiraling.

Netanyahu said earlier Tuesday that Israel was exploring a diplomatic solution, but wouldn't balk at a broader military operation.

"I prefer a diplomatic solution," Netanyahu said in a statement after meeting with Germany's Foreign Minister Guido Westerwelle, who is also in the region trying to advance peace efforts. "But if the fire continues, we will be forced to take broader measures and will not hesitate to do so."

Westerwelle said a truce must be urgently pursued, "but of course, there is one precondition for everything else, and this is a stop of the missile attacks against Israel."

The conflict erupted last week, when a resurgence in rocket fire from Gaza set off the Israeli offensive, which included hundreds of airstrikes on militants' underground rocket launchers and weapons' stores.

The onslaught turned deadlier over the weekend, as airstrikes began targeting the homes of suspected Hamas activists, leading to a spike in civilian casualties. Israel sent warnings in some cases, witnesses said, but in other instances missiles hit suddenly, burying residents under the rubble of their homes.

Hamas is deeply rooted in densely populated Gaza, and the movement's activists live in the midst of ordinary Gazans. Israel says militants are using civilians as human shields, both for their own safety and to launch rocket strikes from residential neighborhoods.

Early Tuesday, Israeli aircraft targeted another Hamas symbol of power, the headquarters of the bank senior Hamas officials set up to sidestep international sanctions on the militant group's rule. The inside of the bank was destroyed. A building supply business in the basement was damaged.

Fuad Hijazi and two of his toddler sons were killed Monday evening when missiles struck their one-story shack in northern Gaza, leaving a crater about two to three meters (seven to 10 feet) deep in the densely populated neighborhood. Residents said the father was not a militant.

The conflict showed signs of spilling into the West Bank, as hundreds of Palestinian protesters in the town of Jenin clashed with Israeli forces during a demonstration against Israel's Gaza offensive.

Two Palestinian protesters were killed in anti-Israel demonstrations in the West Bank on Monday, according to Palestinian officials. Separate clashes occurred Tuesday in Ramallah, the seat of the Palestinian government, during the funeral for one of the dead.

Palestinian President Mahmoud Abbas, who lost control of Gaza to Hamas in 2007, now governs from the West Bank. Abbas claims to represent both areas, and there is widespread sympathy among West Bank Palestinians for their brethren in Gaza.

Israel demands an end to rocket fire from Gaza and a halt to weapons smuggling into Gaza through tunnels under the border with Egypt. It also wants international guarantees that Hamas will not rearm or use Egypt's Sinai region, which abuts both Gaza and southern Israel, to attack Israelis.

Hamas wants Israel to halt all attacks on Gaza and lift tight restrictions on trade and movement in and out of the territory that have been in place since Hamas seized Gaza by force in 2007. Israel has rejected such demands in the past.

___

Associated Press writers Hamza Hendawi in Cairo, and Karin Laub and Ibrahim Barzak in Gaza City, Gaza Strip, contributed to this report.

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U.S. fiscal impact of great concern to Canada: Canada’s Harper

TORONTO (Reuters) – Any fiscal problems that would significantly slow the U.S. economy would be of great concern to Canada, Canadian Prime Minister Stephen Harper said on Monday.

The United States needed a credible medium-term fiscal plan, Harper said at a business forum in Ottawa, adding that he was following the U.S. fiscal debate with “great interest.”

(Reporting by Solarina Ho)

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Phillip Phillips looks at life beyond “American Idol”

LOS ANGELES (Reuters) – Like the 10 winners before him, Phillip Phillips faces the uneven road from “American Idol” victor to pop-chart mainstay.

After the success of his Top 10 hit, “Home,” the Georgia native is facing a new challenge – to replicate the mainstream successes of past “Idol” winners Carrie Underwood and Kelly Clarkson on his debut album, “The World from the Side of the Moon,” released on Monday by Interscope Records.

Phillips, 22, spoke to Reuters about making his first proper studio album, what he might do differently on a second one, and whether he could have won “Idol” with this season’s panel of judges.

Q: How do you plan to transition from “American Idol” winner to a mainstream music career?

A: “It’s pretty funny that you mention that because the majority of the people I meet don’t even know that I was on ‘Idol.’ It’s really cool to hear that. When I go home, people ask, ‘What’ve you been doing? I’ve heard your song,’ but they don’t even know that I’ve been on ‘Idol.’”

Q: Your first single “Home” has gone twice platinum. You’ve said that it isn’t a song you would have written yourself. What’s your relationship now with your first hit?

A: “It’s amazing how well it has done, and I look at all the stories that I hear like how it has helped families out with their situation, or something’s happened with their kid, mom or dad, or if their child’s overseas in the war. Something like that’s pretty amazing how many different stories come out of it.”

Q: Did you have any ideas on how you wanted to develop your sound finally getting into a big-time studio?

A: “I already had the songs written, and it was just a matter of throwing in ideas and then just trimming it down to what felt right, because we only had three weeks to do this album. So it was kind of pressured, but that kind of helped out as well. It didn’t make us overthink anything.”

Q: Was there anything in particular you wanted to achieve?

A: “I wanted to make it similar to what I did on the show – a horn section and some rock. I tried to be a little artistic. I just wrote what came from my heart and what felt right.”

Q: Unlike many of the other contestants, you went into “Idol” as a songwriter, how many of the album’s songs did you write?

A: “I think five. Some of the co-writes, (the writers) really just kind of pushed me, so I kind of wrote most of those myself. But it was a lot of fun; it was a great experience.”

Q: Would you do anything differently next time?

A: “It’s still early, but I’d definitely want a little more time to do it. But that’s really about it, because three weeks is just really quick, and also I have just so many other things going on. … It was very kind of stressful and hopefully for the next record I’ll have a little more time.”

Q: What would that time allow you to do in the studio?

A: “Just being able to listen to it a little more. We all knew that it sounded really good but also having to listen to, like 17 songs in a row. You say, ‘Yeah that sounds great’ but you listen to it more and more and (say) ‘Maybe I would’ve brought this instrument down a little bit or brought it up a little bit more.’”

Q: Would you have fared any differently on ‘Idol’ with the current judges Nicky Minaj and Mariah Carey?

A: “I don’t know. I’m curious to see how they’re going to judge. It’s a completely different panel this year. … I don’t really know how I would’ve turned out. Maybe I’ll have to go out and audition again (laughs).”

Q: Would you have had to change your roots-y style?

A: “Naw, I would’ve still been the same dude. If they wouldn’t have sent me through, they wouldn’t have sent me through. And if they did, that’d be awesome.”

(Reporting By Eric Kelsey, editing by Jill Serjeant and Gunna Dickson)

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Who Are the ‘Anti-Israel’ Press Behind Rupert Murdoch’s Twitter Attack?

Rupert Murdoch can apologize (as he sort of did) about his “Jewish-owned press” tweet, but he still can’t take it back. And because that tweet is out there, the big question now—after “Why is he still on there?” and “Wow, that’s really offensive, right?”—is which press, exactly, he was referring to. Here’s the tweet that Murdoch sent out on Saturday night: 

Why Is Jewish owned press so consistently anti- Israel in every crisis?

— Rupert Murdoch(@rupertmurdoch) November 18, 2012

After an avalanche of Twitter blowback, Murdoch soon faux-apologized…

“,Jewish owned press” have been sternly criticised, suggesting link to Jewish reporters.Don’t see this, but apologise unreservedly.

— Rupert Murdoch(@rupertmurdoch) November 18, 2012

…”don’t see this” being Murdochian for faux-apology.

RELATED: Rupert Murdoch Brightens Every Newsroom He Enters

As the initial round of shock wears off (The Daily Beast’s Peter Beinart eloquently wrote about how stupid and offensive this tweet was), journalists and editors are now actually trying to make some kind of sense of which outlet or outlets Murdoch may have gotten all drunk-uncle-at-Thanksgiving over. So, with the help of journalists on the case, here’s our best attempt at “Murdoch Whispering“: 

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He Is Talking About The New York Times Foreign Policy’s Blake Hounshell put it succinctly: 

FWIW Murdoch was probably referring to the NYT with that weird tweet.

— Blake Hounshell (@blakehounshell) November 18, 2012

And it was shared be Buzzfeed’s Ben Smith:

Wolff also assumes, as I did, that Murdoch’s Jewish-owned press meant the Times guardian.co.uk/commentisfree/…

— Ben Smith (@BuzzFeedBen) November 19, 2012

The reason Smith, Hounshell, and The Guardian‘s Michael Wolff all think it’s a Times-centered attack isn’t just because of an anti-Semitic slam against the Sulzbergers (more on this in a tiny bit) but because of Murdoch’s various “wars” and his rivalry with The New York Times. Back in 2010, as Vanity Fair pointed out, Murdoch was warring with executive editor Bill Keller, and he was seen tweeting dissing the well-liked Times‘s public editor, Margaret Sullivan, not too long ago: 

Amusing fuss over NYT public editor.We see all two million daily subscribers as our very public editors.

— Rupert Murdoch(@rupertmurdoch) November 8, 2012

So maybe this tweet was another pot shot, albeit with more anti-Semitic tone. But as Wolff points out, being Jewish-owned doesn’t even apply to The Times anymore, which kinda makes it even more anti-Semitic if he was just going by the Sulzberger surname:

To describe the Times this way is both quizzical, and we can assume, pointed. Because, as it happens, the Times isn’t, per se, “Jewish”. True, the Sulzbergers, who control the company, were once a prominent Jewish family. But the Times’ chairman and publisher, Arthur Sulzberger, is half-Jewish (on his father’s side) and was raised as an Episcopalian. Murdoch knows this full well. So what he is saying is something more like “Jewish-tainted press”, which, all in all, seems more, not less, antisemitic.

He Was Talking About CNN and the AP If you go to the New York Times report on the whole thing that might be referring to The Times, they point to CNN and the AP. “In an earlier message he had said, “CNN and AP bias to point of embarrassment,” writes The Times‘s Amy Chozick.

RELATED: New York Times Devours Gothamist

He Was Channeling Wendi’s Broken English and Trolling His ‘Minders’ “Curiously, Murdoch’s wife Wendi often uses the word ‘Jewish’in an atonal context – ‘You Jewish, right? I know you Jewish!’– that makes Murdoch’s minders jump.  He may even become more retrograde to bedevil his minders.” wrote Wolff. Based on a life experience which includes very blunt Asian relatives and a large extended family, there is a definite possibility that Wendi might not know how harsh  ”You Jewish, right?” comes off. It’s hard to say the same for Rupert.

RELATED: The Vatican Gets Trendy: Puts Newspaper Online, Plans a Paywall

He Wasn’t Talking About Mother Jones‘s Adam Weinstein: 

*I* don’t own any media. You laid me off in 2008. RT @rupertmurdoch: Why Is Jewish owned press so consistently anti-Israel in every crisis?

— Adam Weinstein (@AdamWeinstein) November 18, 2012

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Why Sanofi’s Zaltrap Deal Won t Help Patients

Nurse administers chemotherapy to patient. Credit: National Cancer Institute.

I got excited when I read the New York Times story Nov. 9 (“Sanofi Halves Price of Cancer Drug Zaltrap After Sloan-Kettering Rejection)”. Zaltrap is an intravenous infusion colon cancer drug for metastatic colorectal cancer that is resistant to or has progressed with platinum-based chemotherapy. With a list price of $ 11,000 per patient per month, Zaltrap is about double the cost of Genentech’s Avastin. Sloan Kettering doctors rejected Zaltrap, claiming it offered no added value over Avastin, because it works no better than Avastin, and costs twice as much. Doctors from Sloan-Kettering Cancer Center, one the United States flagship cancer hospitals, published an op-ed in the NYTimes Oct. 14, titled “In Cancer Care, Cost Matters,” arguing that hospitals need to put their foot down when drugs are outrageously expensive with no added value. They wrote: “Soaring spending has presented the medical community with a new obligation. When choosing treatments for a patient, we have to consider the financial strains they may cause alongside the benefits they might deliver.” The importance of getting bang for your buck, or value in healthcare, has been a huge point in health policy circles in the United States. In fact, politicians of all stripes are quick to point to health outcomes data that show that despite the United States spending in the top tier of all nations for healthcare, health outcomes are far lower. What Sanofi announced in its response Nov. 8 to Sloan-Kettering, one could have easily thought that it was a victory for patients. However, the New York Times headline stating “Sanofi halves price…” is misleading. Sadly, the Zaltrap half-off deal is not a list price reduction at all. It is just a business discount plan for hospitals and oncologists. As Lisa Jane Hubbell, who uses high-cost disease modifying drugs for a noncancerous, chronic condition told me: “It won’t help patients, will it? Our copay will be based on full price, the docs will pocket the extra from insurance companies. It doesn’t really help anyone who is in need of help paying for healthcare.” Another woman with stage IV breast cancer says that she has been deemed ineligible for any discount for her high-priced cancer drugs because she is insured. In general, drug discount plans go to the uninsured. She emailed me: “The drug I took for five years was re-patented three times while I was on it, as I recall. It was orders of magnitude more expensive than the old standby tamoxifen for only a slight advantage in efficacy.” As The Times points out, Medicare patients are unlikely to see a lower price for Zaltrap for a long while until the discount is incorporated into Medicare payment calculations for Part B, which covers physician-administered drugs. In addition, oncologists have long marked up drugs that they administer for insurers and patients. Fortunately, Sloan-Kettering doctors are on the patients’ side and question whether Sanofi’s discount will make Zaltrap more affordable for patients. Peter Bach, MD, told me: “I don’t know if they’re going through steps to ensure reimbursement goes down to follow price or not. I’m hoping that is in their plans. If not, then yes, the windfall goes to providers, and our concern is the costs passed on to patients.” Leonard Saltzman, MD, the op-ed coauthor, and gastroenterology oncologist, from Sloan Kettering also called Sanofi to task for missing the boat in making Zaltrap affordable for patients. But pharmaceutical price fixing is nothing new, according to Frederic Kaye, MD, professor of hematology and oncology at the University of South Florida in Gainesville, Florida. “I saw this happen for the first time in the late 1980s when a veterinary pill levamisole, which cost pennies for the treatment of heartworm, underwent a 100 times price escalation when it was used for treating colon cancer. There was outrage at the time over lack of regulations for price fixing, but you see almost 25 years later, it is the same.” Sanofi’s drug discount plan is clearly a business imperative. If one of the US flagship cancer treatment centers says that they will not use Zaltrap, others could follow. But the refusal to lower Zaltrap’s list price is worrisome because patient copays are based on price. More importantly, if the Sanofi plan becomes the pharmaceutical industry’s modus operandi to the era of value-based healthcare, patients will still remain out in the cold, without any added relief for the high cost of drugs. Value-based healthcare will be something for facilities and hospitals and leave patients out in the cold. These days, you have to critically review the hoopla about “patient-centered health care” and the allegedly positive partnerships shaping healthcare. Were patients included when it really mattered in drafting this drug discount program? We need to maintain a high level of skepticism about deals made strictly between drug companies and hospitals, or arrangements made between industry and physicians, or industry and health plans. It’s been said before and it must be said again: “Nothing about me [the patient] that pertains to me should be done without me at the table.”  

Follow Scientific American on Twitter @SciAm and @SciamBlogs. Visit ScientificAmerican.com for the latest in science, health and technology news.
© 2012 ScientificAmerican.com. All rights reserved.

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Israel says prefers diplomacy but ready to invade Gaza

GAZA/JERUSALEM (Reuters) - Israel bombed dozens of targets in the Gaza Strip on Monday and said that while it was prepared to step up its offensive by sending in troops, it preferred a diplomatic solution that would end Palestinian rocket fire.

Mediator Egypt said a deal for a truce to end the fighting could be close. The leader of Hamas said it was up to Israel to end the new conflict it had started. Israel says its strikes are to halt Palestinian rocket attacks.

U.N. Secretary-General Ban Ki-moon, touring the region in hopes of helping broker a peace arrived in Cairo, where he met Egypt's foreign minister in preparation for talks with the new, Islamist president, Mohamed Mursi, on Tuesday. He also plans to meet Israeli Prime Minister Benjamin Netanyahu in Jerusalem.

Israeli attacks on the sixth day of fighting raised the number of Palestinian dead to 101, the Hamas-run Health Ministry said, listing 24 children among them. Hospital officials in Gaza said more than half of those killed were non-combatants. Three Israeli civilians died on Thursday in a rocket strike.

Militants in the Gaza Strip fired 110 rockets at southern Israel on Monday, causing no casualties, police said.

For the second straight day, Israeli missiles blasted a tower block in the city of Gaza housing international media. Two people were killed there, one of them an Islamic Jihad militant.

Khaled Meshaal, exiled leader of Hamas, said a truce was possible but the Islamist group, in charge of the Gaza Strip since 2007, would not accept Israeli demands and wanted Israel to halt its strikes first and lift its blockade of the enclave.

"Whoever started the war must end it," he told a news conference in Cairo, adding that Netanyahu, who faces an election in January, had asked for a truce, an assertion a senior Israeli official described as untrue.

Meshaal said Netanyahu feared the domestic consequences of a "land war" of the kind Israel launched four years ago: "He can do it, but he knows that it will not be a picnic and that it could be his political death and cost him the elections."

For Israel, Vice Prime Minister Moshe Yaalon has said that "if there is quiet in the south and no rockets and missiles are fired at Israel's citizens, nor terrorist attacks engineered from the Gaza Strip, we will not attack."

Yaalon also said Israel wanted an end to Gaza guerrilla activity in the neighboring Egyptian Sinai peninsula.

Although 84 percent of Israelis supported the current Gaza assault, according to a poll by Israel's Haaretz newspaper, only 30 percent wanted an invasion, while 19 percent wanted their government to work on securing a truce soon.

DIPLOMACY "PREFERRED"

"Israel is prepared and has taken steps, and is ready for a ground incursion which will deal severely with the Hamas military machine," a senior official close to Netanyahu told Reuters.

"We would prefer to see a diplomatic solution that would guarantee the peace for Israel's population in the south. If that is possible, then a ground operation would no longer be required. If diplomacy fails, we may well have no alternative but to send in ground forces," he added.

Egypt, where Mursi has his roots in the Muslim Brotherhood seen as mentors to Hamas, is acting as a mediator in the biggest test yet of Cairo's 1979 peace treaty with Israel since the fall of Hosni Mubarak.

"I think we are close, but the nature of this kind of negotiation, (means) it is very difficult to predict," Egyptian Prime Minister Hisham Kandil, who visited Gaza on Friday in a show of support for its people, said in an interview in Cairo for the Reuters Middle East Investment Summit.

Egypt has been hosting leaders of both Hamas and Islamic Jihad, a smaller armed faction.

Israeli media said a delegation from Israel had also been to Cairo for truce talks. A spokesman for Netanyahu's government declined comment on the matter.

Egypt's foreign minister, who met U.N. chief Ban on Monday, is expected to visit Gaza on Tuesday with a delegation of Arab ministers.

THOUSANDS MOURN FAMILY

Thousands turned out on Gaza's streets to mourn four children and five women, among 11 people killed in an Israeli strike that flattened a three-storey home the previous day.

The bodies were wrapped in Palestinian and Hamas flags. Echoes of explosions mixed with cries of grief and defiant chants of "God is greatest".

The deaths of the 11 in an air strike drew more international calls for an end to six days of hostilities and could test Western support for an offensive Israel billed as self-defense after years of cross-border rocket attacks.

Israel said it was investigating its air strike that brought the home crashing down on the al-Dalu family, where the dead spanned four generations. Some Israeli newspapers said the wrong house may have been mistakenly targeted.

In scenes recalling Israel's 2008-2009 winter invasion of the coastal enclave, tanks, artillery and infantry have massed in field encampments along the sandy, fenced-off border and military convoys moved on roads in the area.

Israel has also authorized the call-up of 75,000 military reservists, so far mobilizing around half that number.

The Gaza fighting adds to worries of world powers watching an already combustible region, where several Arab autocrats have been toppled in popular revolts for the past two years and a civil war in Syria threatens to spread beyond its borders.

In the absence of any prospect of permanent peace between Israel and Islamist factions such as Hamas, mediated deals for each to hold fire unilaterally have been the only formula for stemming bloodshed in the past.

Israel's declared goal is to deplete Gaza arsenals and force Hamas to stop rocket fire that has hit Israeli border towns for years.

Hamas and other groups in Gaza are sworn enemies of the Jewish state which they refuse to recognize and seek to eradicate, claiming all Israeli territory as rightfully theirs.

Hamas won legislative elections in the Palestinian Territories in 2006. A year later, after the collapse of a unity government under President Mahmoud Abbas, the Islamist group seized Gaza in a brief civil war with Abbas's forces.

(Writing by Jeffrey Heller, Dan Williams and Peter Graff; Editing by Alastair Macdonald)

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Canada pledges again to balance budget by 2015

OTTAWA/NEW YORK (Reuters) – The Canadian government on Friday reiterated its intention to balance its budget by 2015, three days after projecting there would be deficits until 2016-17.

In separate appearances in Quebec City and New York, Prime Minister Stephen Harper and Finance Minister Jim Flaherty were at pains to say they still intended to end the red ink by 2015.

“It remains the government’s plan, intention, to balance the budget prior to the next federal election. The recent economic and fiscal update by the minister indicates we are actually very close to that objective,” Harper told reporters in Quebec City. The next election is in October 2015.

Flaherty’s fall fiscal update on Tuesday had pushed back the target date for eliminating the deficit by a year, to 2016-17, citing a weak global economy.

But the minister said in a speech in New York that the government was on track to balance the budget in the next two to three years, barring major external events, and he later clarified that he intended a balanced budget by 2015.

“The prime minister’s always correct,” he chuckled.

He sought to explain the discrepancy by saying the fiscal update had built in a C$ 3 billion ($ 3 billion) contingency cushion, meaning there was an underlying surplus of C$ 1.2 billion for 2015-16. He said the projection of a C$ 1.8 billion deficit amounted to about half a percent of the C$ 275 billion federal budget.

“There’s lots of water to go under the bridge between now and then,” he said.

The opposition New Democratic Party noted the discrepancy in a release headlined: “Stephen Harper makes stuff up about balancing the budget.”

It pointed out that balancing the budget by the next election was not the same as balancing it by 2016-17.

As it is, even the 2015-16 timetable is a year later than offered in the Conservative campaign for reelection in May 2011. They had promised a balanced budget by 2014-15, followed by major personal income tax relief before the 2015 election.

Flaherty’s timetable drew criticism this week from the Canadian Taxpayers Federation, which said the minister had become expert at kicking the can down the road.

The projections could be thrown out of whack if the United States goes off the fiscal cliff, a set of automatic tax hikes and spending cuts that are to be triggered on January 2 if legislators and the White House cannot agree on a more nuanced budget deal.

Flaherty said U.S. failure to avert the fiscal cliff would cause a significant and immediate decline in Canada’s gross domestic product, and he would counter it.

Referring to a possible economic shock from Europe or the United States, he said: “If that were to happen and if the Canadian economy were to be pushed back into recession with the resulting danger for higher unemployment and the danger always of a prolonged recession, then we would act.”

He added: “We would not stand by and let that happen. The kinds of measure we can take: there are various tax measures we can take, there are measures with respect to stimulus we can take, these are things that we have done before and we can do again.”

On Tuesday, Flaherty spoke of having prepared various contingency plans.

(Additional reporting by Louse Egan; Editing by David Gregorio)

Canada News Headlines – Yahoo! News

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Rock band AC/DC releases entire catalog on iTunes

NEW YORK (AP) — AC/DC is finally releasing its music digitally on iTunes.

Columbia Records and Apple announced Monday that the classic rock band’s music will be available at the iTunes Store worldwide. Sixteen studio albums will be released, including “High Voltage” and “Back in Black.”

AC/DC was one of the few acts that would not release music through the digital outlet. The Beatles and Kid Rock were also against selling music on iTunes, but have since jumped onboard. Country star Garth Brooks has yet to release his music on iTunes.

Four of AC/DC’s live albums and three compilation records are also available. The statement said the songs have been mastered for iTunes “with increased audio fidelity.”

Entertainment News Headlines – Yahoo! News

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